I did use REGSVR.32.exe to register aspSmartUpload.dll.
It worked oke.
I downloaded a new aspSmartUpload and installed it the way the setup.htm tell' s you to.
I copied aspSmartUploadUtil to C:\Windows\System32.
I edited the Metabase.xml as told in the setup.
Perhaps it's going wrong with the copying of the files to de C:\Inetpub\Script and C:\Inetpub\wwwroot directory.
The setup tells you to copy the aspSmartupload directory to the above mentioned dirs.
Do you have to splitt these directories your self because the way the setup is telling is a little confusing.